Protein name:
Caldesmon (CDM) ;
Alternative:
Organism:
Chicken (Gallus gallus).
General Annotation
Function:
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping.
Subcellular Location:
Cytoplasm
cytoskeleton
Cytoplasm
myofibril
On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).
Protein Attributes:
50:
MDDFERRREL | RRQKREEMRL | EAERLSYQRN | DDDEEEAARE | RRRRARQERL |
100:
RQKEEGDVSG | EVTEKSEVNA | QNSVAEEETK | RSTDDEAALL | ERLARREERR |
150:
QKRLQEALER | QKEFDPTITD | GSLSVPSRRE | VNNVEENEIT | GKEEKVETRQ |
200:
GRCEIEETET | VTKSYQRNNW | RQDGEEEGKK | EEKDSEEEKP | KEVPTEENQV |
250:
DVAVEKSTDK | EEVVETKTLA | VNAENDTNAM | LEGEQSITDA | ADKEKEEAEK |
300:
EREKLEAEEK | ERLKAEEEKK | AAEEKQKAEE | EKKAAEERER | AKAEEEKRAA |
350:
EERERAKAEE | ERKAAEERER | AKAEEERKAA | EERAKAEEER | KAAEERAKAE |
400:
EERKAAEERA | KAEKERKAAE | ERERAKAEEE | KRAAEEKARL | EAEKLKEKKK |
450:
MEEKKAQEEK | AQANLLRKQE | EDKEAKVEAK | KESLPEKLQP | TSKKDQVKDN |
500:
KDKEKAPKEE | MKSVWDRKRG | VPEQKAQNGE | RELTTPKLKS | TENAFGRSNL |
550:
KGAANAEAGS | EKLKEKQQEA | AVELDELKKR | REERRKILEE | EEQKKKQEEA |
600:
ERKIREEEEK | KRMKEEIERR | RAEAAEKRQK | VPEDGVSEEK | KPFKCFSPKG |
650:
SSLKIEERAE | FLNKSAQKSG | MKPAHTTAVV | SKIDSRLEQY | TSAVVGNKAA |
700:
KPAKPAASDL | PVPAEGVRNI | KSMWEKGNVF | SSPGGTGTPN | KETAGLKVGV |
750:
SSRINEWLTK | TPEGNKSPAP | KPSDLRPGDV | SGKRNLWEKQ | SVEKPAASSS |
771:
KVTATGKKSE | TNGLRQFEKE | P
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Chicken
Rat
ELISA Kit for Chicken CDM
ELISA Kit for Chicken CDM
ELISA Kit for Chicken CDM
ELISA Kit for Chicken CDM
Polyclonal Antibody for Chicken CDM
Polyclonal Antibody for Chicken CDM
Polyclonal Antibody for Chicken CDM
Polyclonal Antibody for Chicken CDM
Monoclonal Antibody for Chicken CDM
Monoclonal Antibody for Chicken CDM
Monoclonal Antibody for Chicken CDM
Monoclonal Antibody for Chicken CDM
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE (ISOFORM GIZZARD H-CAD)
tissue :
Gizzard .
tissue :
Oviduct .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE (ISOFORM GIZZARD H-CAD)
tissue :
Gizzard .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE (ISOFORM BRAIN L-CAD)
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (GIZZARD H-CAD; BRAIN L-CAD AND GIZZARD L-CAD)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GIZZARD L-CAD)
tissue :
Gizzard .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15 (ISOFORM BRAIN L-CAD)
tissue :
Brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 451-756;PARTIAL PROTEIN SEQUENCE
tissue :
Gizzard .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 498-525
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-597; SER-682; THR-688; THR-711 AND SER-717
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-27 AND TYR-165